Blackburn, Everton and Bolton all fell at the hands of lower league opposition.
Blackburn were emphatically beaten by Championship side Coventry 4-1. The goalscorers for Coventry were Elliot Ward, Dele Adebola and a brace from Michael Mifsud, the man who scored twice at Old Trafford in this seasons Carling Cup.
Everton were beaten by League One side Oldham 1-0. The match was delayed by half an hour after a fire in a chip shop outside the ground. Gary McDonald was Oldham's hero after he struck a superb 25-yard strike past Tim Wessels in the Everton goal.
Bolton were beating at the hands of Championship side Sheffield United 1-0. David Carney's first half strike was enough to send the Blades fans home happy.
Birmingham crashed out at League two Huddersfield 2-1. Luke Beckett put Huddersfield in front but just three minutes later the sides were level when Gary O'Connor scored. But Chris Brandon popped up with a goal during the second half to send Alex McLeish's side home disappointed.